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doi: 10.21873/anticanres.12083

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To enhance the predictive value of preclinical research, we should increase the weight of aging models, metabolic syndrome comorbidity models, and large animal long-term follow-up models in the research system, and integrate the PK/PD parameters, dynamic biomarker profiles, and histological data obtained from these more clinically relevant models as important reference thresholds for deciding whether a candidate drug enters clinical trials