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Indeed, FLNA can bind many different partner proteins, including transmembrane proteins, such as several GPCRs, integrins, and ion channels, allowing their anchorage to actin cytoskeleton ( All these interactions are regulated by FLNA phosphorylation, proteolysis, mechanical forces, competition, and multimerization of partners

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*Correspondence: Xijun Wang, [email protected] †These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers