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Under the physiological conditions of the CNS, the glial cells converge to facilitate an efficient synaptic signaling, maintaining a plastic circuitry, clean intercellular space and accelerating pulse conduction with dynamic renewal of the myelin sheath

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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)