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This discovery reveals a key pathological mechanism in RA: DNA repair defects and cellular energy metabolism crisis jointly lead to pathological death of immune cells, such as pyroptosis, while released molecules such as mtDNA act as DAMPs to continuously activate the immune system (107)

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In reproductive immunology, uterine NK cells play essential roles in early pregnancy tolerance through killer cell immunoglobulin-like receptors (Male and Moffett, 2023)